Autism increased by older mens sperm


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11 Jul Scientists have suggested that aging sperm, which has a higher “Maybe older men that have these soft signs of autism marry later in life.

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29 Nov Older men and women are more likely than young ones to have a a grandchild's autism risk, and age alters chemical tags on sperm in mice.

Autism increased by older mens sperm
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A man’s age matters

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- The Washington Post

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Description:Genetics of male aging DNA fragmentation Some of the potential causes of DNA damage in sperm are abnormal protamination or abnormal protamines compaction [ 53 - 55 ]. DNA fragmentation as a result of single or double strand breaks can be measured by two common methods i. TUNEL assay however cannot differentiate between apoptosis and necrosis. Apoptosis in sperm is different from apoptosis seen in somatic cells where it is regulated at the plasma level presence of Fas receptors , nucleus presence of p53 inducing upregulation of Bax gene and down regulation of Bcl-2 expression and cytoplasm activation of Bax and release of cytochrome c and caspase cascade in the cytosol [ 77 - 79 ]. Ejaculated sperm show features characteristic of apoptosis such as ultrastructural observation of the chromatin, mitochondria, the nuclear envelope, plasma membrane, presence of apoptotic bodies and presence of DNA fragmentation and externalization of phosphatidyl serine residues.

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Views: 6379 Date: 2018-07-03 Favorited: 98 favorites

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